Human t ( 4 ; ll ) ( q 21 ; q 23 ) Acute Lymphoblastic Leukemia in Mice With Severe Combined Immunodeficiency
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چکیده
Mice with severe combined immunodeficiency (SCID) were injected intravenously with primary bone marrow blasts from 12 children with newly diagnosed t(4;ll)(q21;q23) acute lymphoblastic leukemia (ALL). Blasts from eight patients caused overt disseminated leukemia, whereas blasts from the other four patients produced occult leukemia that was detectable only by the polymerase chain reaction (PCR) technique. Only one patient among eight whose blasts caused disseminated leukemia in SClD mice remains alive
منابع مشابه
Clinical Characteristics and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia With the t ( 4 ; l l ) ( q 21 ; q 23 ) : A Collaborative Study of 40 Cases
The t(4;11)(q21;q23) chromosomal abnormality was identified in 40 (2%) of 1,986 children with newly diagnosed acute lymphoblastic leukemia (ALL). This translocation was associated with female sex (63%). age less than 1 year (60%). hyperleukocytosis (median leukocyte count, 156.5 x 109/L), CDlO-/CD19+ B-precursor cell immunophenotype, and myeloid-associated antigen (CD15) expression (63%). Nearl...
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Human acute leukemia, with a chromosomal translocation involving chromosomes 4 and 11, t(4;llXq21;q23), is the most common form of leukemia in infants and responds very poorly to conventional therapy. A human CD19* mixed-lineage leukemia cell line with a t(4;llXq21;q23) translocation, RS4;11, disseminated and proliferated in the hematopoietic tissues and other organs of mice with severe combine...
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متن کاملHuman t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Mice with severe combined immunodeficiency (SCID) were injected intravenously with primary bone marrow blasts from 12 children with newly diagnosed t(4;11)(q21;q23) acute lymphoblastic leukemia (ALL). Blasts from eight patients caused overt disseminated leukemia, whereas blasts from the other four patients produced occult leukemia that was detectable only by the polymerase chain reaction (PCR) ...
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